Mar 9, - Clonazepam (Klonopin) Antidepressants have the advantage of relieving depression as well as anxiety, and they are believed to create less. Oct 6, - I know they all pretty much coincide with eachother however, I'm concerned how the Klonopin will affect my OCD and depression or will it help Does klonopin make you feel depressed? It relaxes me. Clonazepam received an overall rating of 7 out of 10 stars from 77 reviews. If I take more than 1/2 a pill at night, I am depressed and lethargic the next day.